Table 5

Comparison of different techniques

Method

Advantage

Disadvantage


Nasal blown secretions

- easy to perform

- subject must be able to blow nose

- no information about mucosa


Nasal lavage

- easy to perform

- luminal proteins, cells, mediators and cytokines

- reliability depends ability of subject to close nasopharynx

- dilution of mediators and cytokines

- variable recovery of fluid

- no information about mucosa


Sinus packs or filter paper

- no/limited dilution of mediators

- may irritate the nose

- cannot collect cells

- no information about mucosa

- more difficult than lavage


Microsuction technique

- no dilution of mediators

- representative sample?

- technically difficult

- cannot collect cells

- no information about mucosa


Nasal brush

- sample of epithelium

- no sample of deeper layers

- no information about nasal lumen

- technically more difficult


Nasal scraping

- sample of epithelium

- no sample of deeper layers

- no information about nasal lumen

- technically more difficult


Nasal NO

- non-invasive

- measure of inflammation and blockage


Nasal biopsy

- sample of total nasal mucosa

- no information about nasal lumen

- technically difficult


Scadding et al. Clinical and Translational Allergy 2011 1:2   doi:10.1186/2045-7022-1-2

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