|Potential manifestations of food allergy eligible for inclusion|
|IgE-mediated (acute-onset)||Acute urticaria/angioedema|
|Oral allergy syndrome (pollen-associated food allergy syndrome)|
|Immediate gastrointestinal hypersensitivity such as vomiting and diarrhoea|
|Cell-mediated (delayed onset/chronic)||Food protein induced gastroenteropathy|
|Food protein-induced enterocolitis syndrome|
|Food protein-induced allergic proctocolitis|
|Allergic contact dermatitis|
|Combined IgE and cell-mediated (delayed onset/chronic)||Atopic eczema/dermatitis|
Food allergy is complex and may manifest as other pathologies. As well as food allergy per se, studies of the following pathologies are eligible for inclusion, as long as there is suspicion of food allergy and the intervention focuses on addressing dietary or food-related issues. Coeliac disease is an important non-IgE mediated condition but as it has distinct symptoms and prognosis different from atopic conditions it will be excluded from this review.
de Silva et al.
de Silva et al. Clinical and Translational Allergy 2013 3:12 doi:10.1186/2045-7022-3-12