Disease-specific health-related quality of life (HRQL) instruments for food allergy: protocol for a systematic review
1 University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
2 St. George’s University, Cranmer Terrace, London SW17 0RE, UK
3 University of Ottawa, 75 Laurier Avenue East, Ottawa, ON K1N 6N5, Canada
4 Padua General University Hospital, Via Giustiniani 3, Padua 35128, Italy
5 Faculty of Medicine, University of Southampton, Southampton SO171BJ, UK
6 Department of General Practice, GRIAC Research Institute, University Medical Center Groningen, PO Box 30.001, Groningen 9700 RB, The Netherlands
7 Department of Paediatrics, University Medical Centre Groningen, Groningen 9700 RB, The Netherland
8 Division of Paediatric Pulmonology and Paediatric Allergy, University Medical Centre Groningen, PO Box 30.001, Groningen 9700 RB, The Netherland
9 University of Groningen, Groningen 9700 RB, The Netherland
10 Centre for Population Health Sciences, The University of Edinburgh Medical School, Doorway 3, Teviot Place, Edinburgh EH8 9AG, UK
Clinical and Translational Allergy 2013, 3:15 doi:10.1186/2045-7022-3-15Published: 1 May 2013
The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management, and impact on quality of life, which will be used to inform clinical recommendations. The aim of this systematic review will be to determine which validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, food allergy on health-related quality of life.
Seven bibliographic databases were searched from their inception to September 30, 2012 for disease-specific HRQL questionnaires that were specifically designed for use with patients/carers and any articles relating to the description, development and/or the validation of the above identified HRQLs. There were no language or geographic restrictions. We will assess the development of the instruments identified and their performance properties including: validity; generalizability; responsiveness; managing missing data; how variation in patient demography was managed; and cross-cultural and linguistic adaptation, using a previously reported quality assessment tool.
Using appropriately developed and validated instruments is critical to the accurate evaluation of HRQL in people with food allergy. This review will systematically appraise the evidence on the subject and help to identify any gaps.