Open Access Highly Accessed Open Badges Study protocol

The epidemiology of anaphylaxis in Europe: protocol for a systematic review

Sukhmeet S Panesar1, Bright I Nwaru2, Lennart Hickstein3, Tamara Rader4, Hala Hamadah5, Dana Fawzi Ibrahim Ali5, Bhavesh Patel6, Antonella Muraro7, Graham Roberts8, Margitta Worm9, Aziz Sheikh10* and on behalf of European Academy of Allergy and Clinical Immunology Food Allergy and Anaphylaxis Guidelines group

Author Affiliations

1 University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK

2 University of Tampere, Kalevantie 4, Tampere, FI-33014, Finland

3 Ludwig-Maximilian-University, Leopoldstr. 3 /018a 80802, Munich, Germany

4 University of Ottawa, 75 Laurier Avenue East, Ottawa, ON, K1N 6N5, Canada

5 St. George’s University, Cranmer Terrace, London, SW17 0RE, UK

6 Open University, Walton Hall, Milton Keynes, Buckingahmshire, MK7 6AA, UK

7 Padua General University Hospital, Via Giustiniani 3, Padua, 35128, Italy

8 Faculty of Medicine, University of Southampton, Southampton, SO171BJ, UK

9 Charité University Charitestraße 1, Berlin, 10117, Germany

10 Centre for Population Health Sciences, The University of Edinburgh Medical School, Doorway 3, Teviot Place, Edinburgh, EH8 9AG, UK

For all author emails, please log on.

Clinical and Translational Allergy 2013, 3:9  doi:10.1186/2045-7022-3-9

Published: 28 March 2013



The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical management and impact on quality of life, which will be used to inform clinical recommendations.

The aims of this systematic review will be to understand and describe the epidemiology of anaphylaxis, i.e. frequency, risk factors and outcomes of anaphylaxis, and describe how these characteristics vary by person, place and time.


A highly sensitive search strategy has been designed to retrieve all articles combining the concepts of anaphylaxis and epidemiology from electronic bibliographic databases.


This review will aim to provide some estimates of the incidence and prevalence of anaphylaxis in Europe. The occurrence of anaphylaxis can have a profound effect on the quality of life of the sufferer and their family. Estimates of disease frequency will help us to ascertain the burden of anaphylaxis and provide useful comparators for management strategies.

Anaphylaxis; Allergy; Epidemiology; Prevalence; Incidence